Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals
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The development of an optimal therapy is, however, complicated by certain side effects, including the possibility of post-treatment hypothyroidism and recurrence of hyperthyroidism following an initial successful treatment
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This debate is reflected in a number of animal models and several human diseases, including careful analysis of human MS (Figure 3